Severe and prolonged hypothyroidism can lead to a decreased level of adrenocortical activity commensurate with the lowered metabolic state. When thyroid-replacement therapy is administered, the metabolism increases at a greater rate than adrenocortical activity. This can precipitate adrenocortical insufficiency. Therefore, in severe and prolonged hypothyroidism, supplemental adrenocortical steroids may be necessary. In rare instances the administration of thyroid hormone may precipitate a hyperthyroid state or may aggravate existing hyperthyroidism.
To treat mild hypothyroidism the recommended starting dose of Cytomel is 25 mcg daily. Usual maintenance dose is 25 to 75 mcg daily. Dosage for other conditions varies. Cytomel may interact with birth control pills or hormone replacement therapy, blood thinners, digoxin, insulin or oral diabetes medication, medications that contain iodine , antidepressants , aspirin or other salicylates, or steroids. Tell your doctor all medications you use. Current information shows Cytomel may be used during pregnancy. Consult your doctor before becoming pregnant. This medication passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breastfeeding.