Folic acid supplements are POSSIBLY INEFFECTIVE or there is INSUFFICIENT EVIDENCE about their effectiveness in prevention or treatment of age-related hearing loss, age-related macular degeneration (AMD), alcoholism , Alzheimer’s disease, bipolar disorder, cancer (breast, cervical, colorectal, esophageal, lung, prostate, stomach), cleft lip, chronic fatigue syndrome (CFS), coronary heart disease, diabetes mellitus, epilepsy (seizures), fragile-X syndrome, gout, gum disease, heart attack or stroke, HIV/AIDS, infertility in men, insomnia, liver disease, muscle pain, nerve pain, osteoporosis, re-blockage of blood vessels after angioplasty, restless leg syndrome, sickle cell anemia, side effects of lometrexol, vitiligo, or improving memory and thinking skills in older people [1,4] .
Terminal prostaglandin synthases have been identified that are responsible for the formation of other prostaglandins. For example, hematopoietic and lipocalin prostaglandin D synthases (hPGDS and lPGDS) are responsible for the formation of PGD 2 from PGH 2 . Similarly, prostacyclin (PGI 2 ) synthase (PGIS) converts PGH 2 into PGI 2 . A thromboxane synthase ( TxAS ) has also been identified. Prostaglandin-F synthase (PGFS) catalyzes the formation of 9α,11β-PGF 2α,β from PGD 2 and PGF 2α from PGH 2 in the presence of NADPH. This enzyme has recently been crystallized in complex with PGD 2  and bimatoprost  (a synthetic analogue of PGF 2α ).
Anabolic steroids have therapeutic use and may be prescribed to treat problems such as muscle degeneration associated with disease, male hormone issues, and late onset of puberty. However, some individuals use anabolic steroids illegally to improve athletic performance and build muscle mass. Abuse of anabolic steroid hormones disrupts the normal production of hormones in the body. There are several negative health consequences associated with anabolic steroid abuse. Some of these include infertility, hair loss, breast development in males, heart attacks, and liver tumors . Anabolic steroids also effect the brain causing mood swings and depression.