When you supplement with Dbol, and this goes for all anabolic steroids it is imperative you live a healthy lifestyle that promotes the continuation of good health. If your blood pressure and cholesterol levels are healthy prior to supplementation, and you shouldn't be supplementing otherwise, continue to live in a way that promotes the continuation of such healthy levels; in-fact, give it more attention. This should not be all that hard to do; after all, you're supplementing for the purpose of performance enhancement, and an unhealthy lifestyle does not promote this end. You bet, this means avoiding excess or heavy alcohol consumption, but it also needs to be avoided due to the C17-aa nature of this steroid as discussed above. Heavy alcohol consumption is extremely hard on the liver, and you don't need the added stress; more so, alcohol itself is the most anti-performance thing you could ever put into your body. While you should avoid excess alcohol, and all alcohol if you want to do things right, you are also encouraged to avoid all over the counter (OTC) medications when possible. Many OTC meds carry extremely strong hepatotoxic natures, some even more so than many anabolic steroids, and their use must be limited to only when truly needed.
The exact dosing instructions for nitric oxide supplement is not known. However, most supplements contain an average dose of grams of L-arginine and L-citrulline. We suggest you follow a process known as tolerance mapping to understand just how much nitric acid is required for your body. The process is simple. All you have to do is start with a small dose in Week 1. During the first week, make sure you note down the benefits and side effects that you are feeling. Once your body has adjusted to the lowest dose possible, you can then increase the dosing until you start feeling beneficial effects. Gradually, your body starts adjusting to the supplement and you will hit your optimal dose. However, the temporary recommendations for the supplement that you can take 2000mg-6000mg per day for optimum effects. Please note that overdosing is possible as dose variations can happen due to physiological differences. In case you notice diarrhea, vomiting, weakness, and nausea, stop the supplement immediately and consult your personal physician. Please note that liquids are absorbed much faster than solids and dosages for liquids will be lower than that of solid preparations.
One of these, PX-866 , has been shown to be a novel, potent, irreversible, inhibitor of PI-3 kinase with efficacy when delivered orally. PX-866 was put in a phase 1 clinical trial by Oncothyreon company.    The clinical development plan for PX-866 includes both standalone and combination therapy in major human cancers.  In 2010 PX-866 was starting 4 phase II trials for solid tumours.  The company gave an update on its phase 2 trials in Jun 2012.  Phase 1 results (with docetaxel) published Aug 2013.  In July 2014 published results of a phase 2 trial (for NSCLC) concluded : "The addition of PX-866 to docetaxel did not improve PFS, response rate, or OS in patients with advanced, refractory NSCLC without molecular preselection".  In Sept 2015 as Phase 2 trial for recurrent glioblastoma reported not meeting its primary endpoint.